Handbook of Carcinogenic Potency and Genotoxicity Databases

CRC Press, Boca Raton, FL, 754 pages, 1997.

Editors - Lois Swirsky Gold

Department of Molecular and Cell Biology, University of California, Berkeley, and Life Sciences Division, Berkeley National Laboratory

and Errol Zeiger

Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina

Description

This reference book contains the Carcinogenic Potency Database (CPDB) published in journal articles through 1992. The book includes analyses of decades of animal cancer tests, including all Technical Reports of the National Toxicology Program (NTP) through 1994 and the general published literature through 1992. A guide to the literature of animal cancer tests, the CPDB includes references to each published experiment and analyses of experimental results.

An index with chemicals listed by CAS number allows cross referencing between the carcinogenicity and genotoxicity databases, making data easy to find.

Features

• Plot of CPDB allows reader easy access to information on each of 5,000 experiments, e.g., design, target sites and tumor incidence, statistics, and carcinogenic potency
• Presents, in a single source, the NTP genetic toxicity test results for 1,500 chemicals
• Provides a table organized by target organ listing carcinogens at each site in rats, mice, hamsters, monkeys, and dogs
• Provides a summary table, by chemical, of results on positivity and carcinogenic potency in each species
• Original experimental results and test data are completely referenced
• Overview and Update of Analyses of the Carcinogenic Potency Database, including interpretation of positive results in cancer bioassays and ranking possible cancer hazards at average human exposure levels.

Table of Contents

Chapter 1
Carcinogenic Potency Database......................................................................p 1
Lois Swirsky Gold, Thomas H. Slone, Neela B. Manley, Georganne Backman Garfinkel, Lars Rohrbach
and Bruce N. Ames

	Section A: Methods of the Carcinogenic Potency Database....................................p 1
	Section B: Guide to the Plot of the Carcinogenic Potency Database..........................p 9
	Section C: Plot of Cancer Test Results.....................................................p 17
	Section D: Appendices of Codes and Definitions.............................................p 543
		Appendix 1: Species................................................................p 543
		Appendix 2: Strains................................................................p 545
		Appendix 3: Routes of Administration...............................................p 547
		Appendix 4: Site Codes.............................................................p 549
		Appendix 5: Histopathology of the Carcinogenic Potency Database....................p 551
		Appendix 6: Notecodes..............................................................p 555
		Appendix 7: Dose-Response Curve Symbols............................................p 557
		Appendix 8: Statistical Methods for Estimating TD50................................p 559
		Appendix 9: Author's Opinion.......................................................p 561
		Appendix 10: Berkeley Codes........................................................p 563
		Appendix 11: Journals..............................................................p 565
		Appendix 12: Synonyms for Chemicals in the Carcinogenic Potency Database...........p 567
	Section E: Carcinogenicity Bibliography....................................................p 573
		Part 1: Carcinogenicity Bibliography -- NCI/NTP Technical Reports..................p 573
		Part 2: Carcinogenicity Bibliography -- General Literature.........................p 577

Chapter 2
Summary of the Carcinogenic Potency Database by Target Organ.......................................p 607
Lois Swirsky Gold, Neela B. Manley, and Thomas H. Slone

Chapter 3
Summary of the Carcinogenic Potency Database by Chemical...........................................p 621
Lois Swirsky Gold, Thomas H. Slone, and Bruce N. Ames

	Section A: Summary of Chemical Carcinogenicity in Rats and Mice............................p 624
	Section B: Summary of Chemical Carcinogenicity in Hamsters.................................p 658
	Section C: Summary of Chemical Carcinogenicity in Nonhuman Primates and Dogs...............p 660

Chapter 4
Overview and Update of Analyses of the Carcinogenic Potency Database...............................p 661
Lois Swirsky Gold, Thomas H. Slone, and Bruce N. Ames

Chapter 5
Genotoxicity Database..............................................................................p 687
Errol Zeiger

	Section A: Description of Genotoxicity Tests...............................................p 687
	Section B: Table of Genotoxicity Results...................................................p 694
	Section C: Genotoxicity Bibliography.......................................................p 726

Chapter 6
Index of Chemical Names in the Carcinogenic Potency (CPDB) and Genotoxicity (GT) Databases
by Chemical Abstract Service (CAS) Registry Number.................................................p 731

To order, contact CRC Press at 1-800-272-77337 (phone) or 1-800-374-3401 (FAX).

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Last updated: August 6, 2007