N,N-Diethyl-4-(4′-[pyridyl-1′-oxide]azo)aniline (CAS 7347-49-1)
SMILES, InChI and Structure are below.
Rats and Mice: Cancer Test Summary
| liv |
no test |
no test |
no test |
<1.63P |
no test |
Key to the Table Above
Positivity:
For each chemical with a positive (carcinogenic) experiment in the
Carcinogenic Potency Database (CPDB), results are included
on carcinogenic potency (TD50) in each species and target sites in males and females.
Positivity is determined by an author’s opinion in a published paper.
If all experimental results in the CDPB are negative in a sex-species group, “no positive” appears.
If the CPDB has no experiments in the sex-species group, “no test” appears.
The summary presents the strongest evidence of carcinogenicity in
each group. If there are both positive and negative
experiments in a sex-species, the negative results are
ignored in this Summary Table.
Target Site Codes:
liv = liver.
Target sites are listed if any author of published experimental results concluded that tumors were
induced in that organ by the test agent.
If there is more than one positive experiment in
a sex-species, target sites listed may be from more than one
experiment, e.g. if liver and lung are both listed, then liver may have
been a target in one experiment and lung in another.
TD50:
Our standardized measure of carcinogenic potency,
TD50,
is the daily dose rate in mg/kg body weight/day to induce tumors in half of test animals that would have
remained tumor-free at zero dose.
Whenever there is more than one positive experiment in a species, the reported TD50 value is a
Harmonic Mean
calculated using the TD50 value from the most potent target site in each positive experiment.
Superscripts:
P =
100% of dosed animals had tumors at a target site in an experiment in this species.
< =
For the only target site in the species, 100% of dosed animals had tumors. The
value reported is the upper 99% confidence limit on TD50; no TD50 could be
calculated because only summary data (not lifetable) were available. A TD50 value
would be less than the reported upper confidence limit.
The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of
6540 chronic, long-term animal cancer tests on 1547 chemicals. The CPDB provides easy access to the bioassay
literature, with qualitative and quantitative analyses of both positive and negative experiments that have been
published over the past 50 years in the general literature through 2001 and by the National Cancer
Institute/National Toxicology Program through 2004. The CPDB standardizes the diverse literature of cancer
bioassays that vary widely in protocol, histopathological examination and nomenclature, and in the published
author’s choices of what information to provide in their papers. Results are reported in the CPDB for
tests in rats, mice, hamsters, dogs, and nonhuman primates.
For each experiment, information is included on species, strain, and sex of test animal; features of experimental
protocol such as route of administration, duration of dosing, dose level(s) in mg/kg body weight/day, and
duration of experiment; experimental results are provided on target organ, tumor type, and tumor incidence;
carcinogenic potency (TD50) and
its statistical significance; shape of the dose-response, author’s opinion as to carcinogenicity, and
literature citation.
Only tests with dosing for at least ¼ the standard lifespan of the species and experiment length
at least ½ the lifespan are included in the CPDB.
Only routes of administration with whole body exposure are included. Doses are
standardized, average dose rates in mg/kg/day.
A description of methods used in the CPDB to standardize the diverse literature of animal cancer tests is
presented for:
1) Criteria for inclusion of experiments
2) Standardization of average daily dose levels and
3) TD50 estimation for a standard lifespan.
See
Methods
for other details.
TD50 provides a standardized quantitative measure that can be used for comparisons and
analyses of many issues in carcinogenesis. The range of TD50 values across chemicals that
are rodent carcinogens is more than 100 million-fold.
More than half the chemicals tested are positive in at least one experiment.
A plot of all results on each experiment in the CPDB for this chemical is presented below.
These results are the source information for the Cancer Test Summary table above.
N,N-Diethyl-4-(4′-[pyridyl-1′-oxide]azo)aniline: All Experiments and Citations in CPDB
The definition of each code in the plot below will appear in a pop-up window when the field
name in the header line is clicked, e.g.,
Strain,
Site,
Path.
Each numbered line starts a new experiment and reports protocol information in black.
Average daily dose-rates per kg body weight per day are in
green. Remaining lines report
experimental results in
blue.
Abbreviations of fields in header line:
# = the line number in the plot of
all CPDB chemicals;
Xpo = duration of dosing;
Xpt = duration of experiment;
Site = tissue;
Path = tumor type;
DR = dose-response;
AuOp = author’s opinion about carcinogenicity;
LoConf, UpConf = confidence limits (99%) on TD
50;
Inc = tumor incidence for each dose group.
See
Guide to reading the plot for details on each field, using an example of one experiment.
See
Help
to improve readability, or to fit the plot onto the screen or a printed page.
Chemical (Synonym) CAS
# Species Sex Strain Route Xpo+Xpt PaperNum 0 Dose 1 Dose 2 Dose 3 Dose Literature Reference or NCI/NTP:Site Path
Site Path Notes TD50 DR Pval AuOp LoConf UpConf Cntrl 1 Inc 2 Inc 3 Inc Brkly Code
N,N-DIETHYL-4-(4'-[PYRIDYL-1'-OXIDE]AZO)ANILINE 7347-49-1
2130 R m sda eat 52w52 1176 0 12.0mg Brown;jnci,37,365-367;1966
liv tum bfr noTD50 P<.0005 + n.s.s. 1.63mg 0/10 10/10
SMILES Code for N,N-Diethyl-4-(4′-[pyridyl-1′-oxide]azo)aniline: [O-][N+](C=C2)=CC=C2/N=N/C1=CC=C(N(CC)CC)C=C1
InChI Code for N,N-Diethyl-4-(4′-[pyridyl-1′-oxide]azo)aniline: InChI=1/C15H18N4O/c1-3-18(4-2)15-7-5-13(6-8-15)16-17-14-9-11-19(20)12-10-14/h5-12H,3-4H2,1-2H3/b17-16+
Source for SMILES and InChI: USEPA Distributed Structure-Searchable Toxicity (DSSTox) Database
Chemical Structure for N,N-Diethyl-4-(4′-[pyridyl-1′-oxide]azo)aniline:
Source for structure: National Library of Medicine ChemIDPlus
See full CPDB Summary Table on 1547
chemicals. See Full CPDB for all results on 6540
experiments of 1547 chemicals.
A complete list of CPDB chemicals, which is searchable by name or by CAS number, is available
here.
For a compendium of CPDB results organized by target organ, which lists all chemicals in each species that
induced tumors in each of 35 organs, see Summary Table by Target Organ.
The CPDB is available in several formats that permit printing
and downloading into spreadsheets and statistical databases.
- A plot of the CPDB presents results
of 1547 experiments on 6540 chemicals in an easily readable format that has been used in publications of the CPDB.
- A Screen version plot for use
on a single computer screen, with the same data.
- Excel version of the same data.
- Tab-separated versions of the same data, which can
be easily read into databases.
A Supplementary Dataset gives details
on dosing and survival for each experiment.
Relatively precise estimates of the lower confidence limit on the
TD10 (LTD10) are readily calculated from
the TD50 and its lower confidence limit, which are reported in the CPDB.
For researchers and regulatory agencies interested in LTD10 values, we provide them in an
Excel spreadsheet.
PDF versions of our publications of analyses using the CPDB are available, organized by
year and by research topic.
Carcinogenic Potency Database Project (CPDB) Home Page
For more information about this Web Page, contact Lois Swirsky Gold, Ph.D. (cpdb@potency.berkeley.edu).
Last updated: October 3, 2007